Descend into anonymity while Brazil retain the title and the barbs are already waiting.
The Selecao has won its last seven finals including three against Argentina , while Argentina has lost its last six finals half via penalty-kick shootout.
La Albiceleste has won the last two meetings and is on a 26-game unbeaten run overall.
Meanwhile, Bolivia, already out of the running to qualify for Qatar 2022, will try to end Brazil's fantastic run and give their fans something to cheer about in what will be the team's last match of this edition of the South American qualifiers.
Here, check out the preview, predictions and odds.
The margin for error will be much smaller for Argentina this weekend, and after seeing some issues throughout the competition, they might land just short of a championship.
The draw for the 2022 World Cup have been conducted on Friday.
Following a grueling path through the group stage and the knockout round, only two teams remain in the South American competition.